GLYR1 antibody

Catalog No. ABIN7114720

This Rabbit Polyclonal antibody specifically detects GLYR1 in WB, ELISA, IHC and IF. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for GLYR1 antibody (ABIN7114720)

Target: GLYR1 (Glyoxylate Reductase 1 Homolog (GLYR1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GLYR1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-GLYR1 Antibody

Purpose: GLYR1 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: cytokine-like nuclear factor n-pac

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000, IHC: 1:20-1:200, IF: 1:20-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for GLYR1

Target: GLYR1 (Glyoxylate Reductase 1 Homolog (GLYR1))

Alternative Name: GLYR1

Background:

Synonyms: Cytokine-like nuclear factor N-PAC (NPAC)|3-hydroxyisobutyrate dehydrogenase-like protein|Glyoxylate reductase 1 homolog|Nuclear protein NP60|Nuclear protein of 60 kDa|Nucleosome-destabilizing factor (hNDF)|Putative oxidoreductase GLYR1|GLYR1|HIBDL|NDF|NP60|NPAC

Background: May have oxidoreductase activity. Regulates p38 MAP kinase activity by mediating stress activation of p38alpha/MAPK14 and specifically regulating MAPK14 signaling. Indirectly promotes phosphorylation of MAPK14 and activation of ATF2. The phosphorylation of MAPK14 requires upstream activity of MAP2K4 and MAP2K6. Recruited on chromatin, recognizes and binds trimethylated 'Lys-36' of histone H3(H3K36me3).

Molecular Weight: 60 kDa

Gene ID: 84656

UniProt: Q49A26